878162-08-4

Usage

Chemical class

Piperazine derivative
A compound that includes a piperazine ring in its molecular structure.

Molecular structure

Piperazine ring, carboxamide group, phenyl and chlorophenyl moieties
A complex structure that contributes to its potential pharmacological properties.
3. Potential pharmaceutical applications
May be used in the development of new drugs for various therapeutic applications.

Pharmacological properties

Unknown, requires further research
The specific properties and potential uses are not yet fully understood and require additional investigation.

Upstream product

• 514170-00-4 1-[(2,4-dichlorophenyl)(phenyl)methyl]piperazine 
• 3066-44-2 diphenylmethyl isocyanate 

Relevant academic research and scientific papers

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.

Urea derivatives as calcium channel blockers

Urea derivatives which comprise piperidine or piperazine rings and further substitution are effective in ameliorating conditions characterized by unwanted calcium ion channel activity.