87818-06-2

Basic information

• Product Name: 5-Fluoro-6-iodouridine
• Synonyms: 5-Fluoro-6-iodouridine
• CAS NO: 87818-06-2
• Molecular Formula: C9H10FIN2O6
• Molecular Weight: 388.0883732
• Mol File: 87818-06-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 2.31
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Fluoro-6-iodouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-6-iodouridine(87818-06-2)
• EPA Substance Registry System: 5-Fluoro-6-iodouridine(87818-06-2)

Safety Data

• Hazardous Substances Data: 87818-06-2(Hazardous Substances Data)

Usage

General Description

5-Fluoro-6-iodouridine is a chemical compound that is a derivative of uridine, a nucleoside found in RNA. It is a modified nucleoside containing fluorine and iodine atoms. 5-Fluoro-6-iodouridine is used in the field of medicinal chemistry, particularly in the development of nucleoside analogs for therapeutic purposes. It is also used as a research tool in the study of nucleic acid structure and function. 5-Fluoro-6-iodouridine has potential applications in the treatment of viral infections and cancer, as well as in the development of novel pharmaceuticals. Its unique chemical structure and properties make it a valuable tool in drug discovery and biochemical research.

Upstream product

• 1134188-90-1 5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylidene-5-fluoro-6-iodouridine 
• 2797-17-3 2',3'-O-isopropylidene-5-fluorouridine 
• 87817-91-2 5-Fluoro-1-((3aR,4R,6R,6aR)-6-methoxymethoxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidine-2,4-dione 
• 87818-01-7 5-Fluoro-6-iodo-1-((3aR,4R,6R,6aR)-6-methoxymethoxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides

A new family of thirteen phosphoramidate prodrugs (ProTides) of different 6-substituted-5-fluorouridine nucleoside analogues were synthesized and evaluated as potential anticancer agents. In addition, antiviral activity against Chikungunya (CHIKV) virus was evaluated using a cytopathic effect inhibition assay. Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P–N bond cleavage and free nucleoside 5′-monophosphate delivery. Our observations may support and explain to some extent the poor in vitro biological activity generally demonstrated by the series of 6-substituted-5-fluorouridine phosphoramidates (ProTides) and will be of guidance for the design of novel phosphoramidate prodrugs.

ODCASE INHIBITORS FOR THE TREATMENT OF MALARIA

The present invention includes methods of treating or preventing malaria by administering an anti-malarial effective amount of 6-substituted uridine derivatives to a subject need thereof. The invention also includes new 6-substituted uridine derivatives for use as therapeutics, in particular to treat malaria.