87818-06-2

Usage

Uses

Used in Medicinal Chemistry:
5-Fluoro-6-iodouridine is utilized as a nucleoside analog in the development of therapeutic agents, leveraging its unique structure to target specific biological processes and diseases.
Used in Research:
As a research tool, 5-Fluoro-6-iodouridine aids in the investigation of nucleic acid structure and function, providing insights into the fundamental mechanisms of RNA biology and its role in various cellular processes.
Used in Antiviral and Anticancer Treatments:
5-Fluoro-6-iodouridine is explored for its potential applications in treating viral infections and cancer due to its ability to interfere with nucleic acid synthesis and function, thereby inhibiting the replication and proliferation of pathogens and tumor cells.
Used in Pharmaceutical Development:
5-Fluoro-6-iodouridine is employed in the creation of novel pharmaceuticals, capitalizing on its distinctive chemical properties to design drugs with improved efficacy and selectivity for various therapeutic targets.

Upstream product

• 1134188-90-1 5'-O-(t-butyldimethylsilyl)-2',3'-O-isopropylidene-5-fluoro-6-iodouridine 
• 87817-91-2 5-Fluoro-1-((3aR,4R,6R,6aR)-6-methoxymethoxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidine-2,4-dione 
• 87818-01-7 5-Fluoro-6-iodo-1-((3aR,4R,6R,6aR)-6-methoxymethoxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidine-2,4-dione 
• 2797-17-3 2',3'-O-isopropylidene-5-fluorouridine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides

A new family of thirteen phosphoramidate prodrugs (ProTides) of different 6-substituted-5-fluorouridine nucleoside analogues were synthesized and evaluated as potential anticancer agents. In addition, antiviral activity against Chikungunya (CHIKV) virus was evaluated using a cytopathic effect inhibition assay. Although a carboxypeptidase Y assay supported a putative mechanism of activation of ProTides built on 5-fluorouridine with such C6-modifications, the Hint docking studies revealed a compromised substrate-activity for the Hint phosphoramidase-type enzyme that is likely responsible for phosphoramidate bioactivation through P–N bond cleavage and free nucleoside 5′-monophosphate delivery. Our observations may support and explain to some extent the poor in vitro biological activity generally demonstrated by the series of 6-substituted-5-fluorouridine phosphoramidates (ProTides) and will be of guidance for the design of novel phosphoramidate prodrugs.

Structure-activity relationships of orotidine-5′-monophosphate decarboxylase inhibitors as anticancer agents

A series of 6-substituted and 5-fluoro-6-substituted uridine derivatives were synthesized and evaluated for their potential as anticancer agents. The designed molecules were synthesized from either fully protected uridine or the corresponding 5-fluorourid

ODCASE INHIBITORS FOR THE TREATMENT OF MALARIA

The present invention includes methods of treating or preventing malaria by administering an anti-malarial effective amount of 6-substituted uridine derivatives to a subject need thereof. The invention also includes new 6-substituted uridine derivatives for use as therapeutics, in particular to treat malaria.

Synthesis and biological activities of 5-substituted 6-phenylthio and 6-iodouridines, a new class of antileukemic nucleosides

A new class of 5,6-disubstituted uridines, in which the C-6 position was occupied by phenylthio group or iodine, were synthesized via lithiation of the corresponding 5-substituted 2',3'-O-isopropylidene-5'-O-methoxymethyl-uridines and subsequent electroph