878205-15-3Relevant academic research and scientific papers
Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
Tremblay, Martin R.,Nevalainen, Marta,Nair, Somarajan J.,Porter, James R.,Castro, Alfredo C.,Behnke, Mark L.,Yu, Lin-Chen,Hagel, Margit,White, Kerry,Faia, Kerrie,Grenier, Louis,Campbell, Matthew J.,Cushing, Jill,Woodward, Caroline N.,Hoyt, Jennifer,Foley, Michael A.,Read, Margaret A.,Sydor, Jens R.,Tong, Jeffrey K.,Palombella, Vito J.,McGovern, Karen,Adams, Julian
supporting information; experimental part, p. 6646 - 6649 (2009/11/30)
Herein is reported the synthesis of a novel class of hedgehog antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed rearran
