878285-14-4

Usage

Uses

Used in Pharmaceutical Industry:
2,5-difluoro-4-methylaniline is used as a building block for the production of various pharmaceuticals. Its strong nucleophilic properties and ability to undergo different chemical reactions make it a valuable intermediate in the synthesis of a wide range of medicinal compounds.
Used in Dye Industry:
2,5-difluoro-4-methylaniline is used as a precursor in the synthesis of dyes. Its unique chemical structure allows for the creation of dyes with specific properties, such as color, stability, and solubility, which are essential for various applications in textiles, plastics, and other industries.
Used in Agrochemical Industry:
2,5-difluoro-4-methylaniline is used as a key intermediate in the production of agrochemicals. Its versatility in chemical reactions enables the development of effective and targeted agrochemicals for crop protection and pest control.
However, it is important to note that 2,5-difluoro-4-methylaniline is a hazardous substance and should be handled with care due to its potential health and environmental risks. Proper safety measures and precautions should be taken during its production, storage, and use to minimize any adverse effects.

Upstream product

• 106-49-0 p-toluidine 

Relevant academic research and scientific papers

Preparation method of 2,4,5-trifluorophenylacetic acid

The invention belongs to the technical field of preparation of drug intermediates, and discloses a preparation method of 2,4,5-trifluorophenylacetic acid, wherein the preparation method comprises the steps: step 1, reacting raw materials, a quaternary ammonium salt catalyst, sulfolane and potassium fluoride to obtain a first intermediate; step 2, carrying out hydrogenation catalytic reaction on the first intermediate to obtain a second intermediate; step 3, carrying out salt forming reaction on the second intermediate and a fluorinating reagent, quenching, and carrying out diazotization reaction on the second intermediate and a sodium nitrite aqueous solution to obtain diazonium salt; step 4, carrying out high-temperature cracking on the diazonium salt, to obtain 2,4,5-trifluorotoluene; and step 5 to step 7, carrying out halogenation, cyanidation and hydrolysis reactions on 2,4,5-trifluorotoluene in sequence, and thus obtaining 2,4,5-trifluorophenylacetic acid. The raw materials adopted by the method are easy to obtain and low in cost, the yield of the corresponding product obtained in each step is high, and large-scale production of the 2,4,5-trifluorophenylacetic acid is facilitated.

2-(2-FLUORO-SUBSTITUTED PHENYL)-6-AMINO-5-CHLORO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES

2-(2-Fluoro-substituted phenyl)-6-amino-5-chloro-4-pyrimidine-carboxylic acid and its derivatives are potent herbicides demonstrating a broad spectrum of weed control.

Electrophilic aromatic fluorination with fluorine: meta-Directed fluorination of anilines

Anilines are mainly or selectively fluorinated in the meta-position with F2 when dissolved in triflic acid, sometimes in the presence of small quantities of antimony pentafluoride. The regioselectivity is increased when an electron-donating substituent is present at the para-position.