878391-33-4

Upstream product

• 5071-96-5 3-METHOXYBENZYLAMINE 
• 106-89-8 epichlorohydrin 

Downstream Products

• 111043-37-9 (3-chloro-2-trimethylsilyloxypropyl)-(3-methoxybenzyl)amine 
• 111043-53-9 1-(3-methoxybenzyl)-azetidine-3-ol 
• 111043-47-1 1-(3-methoxybenzyl)-3-trimethylsilyloxy-azetidine 

Relevant academic research and scientific papers

2-ARYLMETHYLAZETIDINE CARBAPENEM DERIVATIVES AND PREPARATION THEREOF

A 2-arylmethylazetidine carbapenem derivative of formula ( I ) or a pharmaceutically acceptable salt thereof exhibits a wide spectrum of antibacterial activities against Gram-positive and Gram-negative bacteria and excellent antibacterial activities against resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and quinolone-resistant strains (QRS).

Preparation of 3-Azetidinols with Non-Bulky 1-Alkyl Substituents

Cyclization of either the tetrahydropyranyl or trimethylsilyl ether of 1-(alkylamino)-3-chloro-2-propanols 1 followed by cleavage of the azetidinyl ether provides a general method for the preparation of 1-alkyl-3-azetidinols.Unhindered amines provide a more facile preparation of derivatives of 1, or its ethers, than do hindered amines, while hindered derivatives of 1 undergo more facile ring closure.