878406-95-2Relevant academic research and scientific papers
Novel 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs)
Yoon, Young Ae,Kim, Dong Hoon,Lee, Byoung Moon,Kim, Tae Kyun,Cha, Myung Hun,Sim, Jae Young,Kim, Jae Gyu
scheme or table, p. 5237 - 5240 (2010/10/18)
A series of 1H-pyrrolo[2,3-c]pyridines as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H+/K+ ATPase isolated from hog gastric mucosa were determined. After elaborating on substituents at N1, C5, and C7 position of 1H-pyrrolo[2,3-c]pyridine scaffold, we have observed that compounds 14f and 14g are potent APAs with H +/K+ ATPase IC50 = 28 and 29 nM, respectively.
