878480-48-9

Upstream product

• 76173-08-5 1-(4-bromo-phenyl)-pent-4-en-1-one 
• 878480-34-3 1-(benzenesulfonyl)-2-(4-bromophenyl)-1-(phenylsulfanyl)hex-5-en-2-ol 
• 878480-30-9 2-(4-bromobenzoyl)pent-4-enoic acid ethyl ester 

Downstream Products

• 878480-55-8 2-(4-bromophenyl)-2-(phenylsulfanyl)cyclohept-4-enone 

Relevant academic research and scientific papers

Synthesis of 2-arylcycloalka-2,4-dienones using sulfone-based methodology

Addition of the anion derived from (phenylthiomethyl)phenyl sulfone to a selection of aryl ω-alkenyl ketones gives adducts that via a sequence of Lewis acid catalyzed rearrangement, α-allylation, and metathesis give rise to 2-thio-4-cycloalkenones. These in turn give cycloalkadienones upon oxidation and elimination. An attempt to develop a polymer-supported variant fails because of the reversibility of sulfone anion addition.