878541-82-3Relevant academic research and scientific papers
Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold
Dodd, Dharmpal S.,Sheriff, Steven,Chang, ChiehYing J.,Stetsko, Dawn K.,Phillips, Linda M.,Zhang, Yingru,Launay, Michele,Potin, Dominique,Vaccaro, Wayne,Poss, Michael A.,McKinnon, Murray,Barrish, Joel C.,Suchard, Suzanne J.,Murali Dhar
, p. 1908 - 1911 (2007/10/03)
A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described. Elaboration of the 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold resulted in the synthesis of potent inhibitors of the LFA-1/ICAM-1 interaction. Along with the in vi
