878662-35-2Relevant academic research and scientific papers
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake
Cashman, John R.,Voelker, Troy,Zhang, Han-Ting,O'Donnell, James M.
, p. 1530 - 1539 (2009)
A new class of multitarget compounds was synthesized by linking a novel selective serotonin reuptake inhibitor (SSRI) to a PDE4 inhibitor. The new dual PDE4 inhibitor/SSRI showed antidepressant-like activity in the forced swim test in mice The SSRIs 2-{5-
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors
Voelker, Troy,Xia, Haiji,Fandrick, Keith,Johnson, Robert,Janowsky, Aaron,Cashman, John R.
experimental part, p. 2047 - 2068 (2009/06/06)
Enhancement of 5-hydroxytryptamine (5-HT, serotonin) neurotransmission is a viable means of treating depression. On the basis of this observation, agents that inhibit re-uptake of 5-HT were prepared based on (-)-cocaine and aryltropanes as lead compounds
MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS
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Page/Page column 93; 137, (2010/10/20)
Disclosed are agents having pharmacological activity against cellular receptors and intracellular singaling, particularly receptors and sigaling pathways of central nervous system (CNS) neurotransmitters. Also disclosed are related methods and compositions for the treatment or prevention of diseases or disorders using the agents.
