878722-86-2

Upstream product

• 254909-27-8 (2R,5S)-7-ethoxycarbonyl-2-phenyl-1-aza-3-oxa-lbicyclo<3.3.0>octan-8-one 
• 103201-79-2 (3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 5798-79-8 bromo-phenyl-acetonitrile 
• 878722-66-8 (2R,5S,7R,1'S)-1-aza-7-(1'-cyano-1'-phenylmethyl)-7-(ethoxycarbonyl)-3-oxo-8-oxa-2-phenylbicyclo[3.3.0]octane 

Downstream Products

• 878722-91-9 (3S,5S,9S)-3-hydroxymethyl-9-phenyl-2,7-diazaspiro[4.4]nonane-1,6-dione 
• 878722-96-4 (3S,5S,9S)-3-methyloxycarbonyl-9-phenyl-2,7-diazaspiro[4.4]nonane-1,6-dione 

Relevant academic research and scientific papers

Spirocyclic systems derived from pyroglutamic acid

The synthesis and likely conformational structure of rigid spirocyclic bislactams and lactam-lactones derived from pyroglutamic acid, and their suitability as lead structures for applications in drug development programmes using cheminformatic analysis, has been investgated.