878750-06-2Relevant academic research and scientific papers
PARAMAGNETIC METAL COMPLEXES FOR THE MRI VISUALIZATION OF INTERNALIZED POLYNUCLEOTIDES
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Page/Page column 12; 26, (2008/06/13)
The invention relates to paramagnetic ion-based contrast agents that are positively charged at physiological pH and that bind non covalently to a polynucleotide chain for use in the preparation of a diagnostic formulation for the "in vivo" visualization of polynucleotides internalized into human or animal body cells by use of Magnetic Resonance Imaging techniques.
In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes
Crich, Simonetta Geninatti,Cabella, Claudia,Barge, Alessandro,Belfiore, Simona,Ghirelli, Cristina,Lattuada, Luciano,Lanzardo, Stefania,Mortillaro, Armando,Tei, Lorenzo,Visigalli, Massimo,Forni, Guido,Aime, Silvio
, p. 4926 - 4936 (2007/10/03)
The glutamine transporting system is up-regulated in tumor cells because cell proliferation requires the uptake of large quantities of glutamine. It has been found that the paramagnetic magnetic resonance imaging (MRI) reporter Gd-DOTAMA-C6-Gln
