878750-06-2Relevant academic research and scientific papers
In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes
Crich, Simonetta Geninatti,Cabella, Claudia,Barge, Alessandro,Belfiore, Simona,Ghirelli, Cristina,Lattuada, Luciano,Lanzardo, Stefania,Mortillaro, Armando,Tei, Lorenzo,Visigalli, Massimo,Forni, Guido,Aime, Silvio
, p. 4926 - 4936 (2007/10/03)
The glutamine transporting system is up-regulated in tumor cells because cell proliferation requires the uptake of large quantities of glutamine. It has been found that the paramagnetic magnetic resonance imaging (MRI) reporter Gd-DOTAMA-C6-Gln
PARAMAGNETIC METAL COMPLEXES FOR THE MRI VISUALIZATION OF INTERNALIZED POLYNUCLEOTIDES
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Page/Page column 12; 26, (2008/06/13)
The invention relates to paramagnetic ion-based contrast agents that are positively charged at physiological pH and that bind non covalently to a polynucleotide chain for use in the preparation of a diagnostic formulation for the "in vivo" visualization of polynucleotides internalized into human or animal body cells by use of Magnetic Resonance Imaging techniques.
