87884-40-0Relevant academic research and scientific papers
PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-HYDROXYPROPIONIC ESTER DERIVATIVE
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Page/Page column 12, (2010/02/13)
The present invention is to provide a process for simply producing an optically active 3-hydroxypropionic ester derivative useful as a medicament intermediate from an inexpensive material. More specifically, the present invention is directed to a process for producing an optically active 3-hydroxypropionic ester derivative comprising reacting an acetic ester derivative available at low cost with a base and a formic ester, thereby converting the acetic ester derivative into a 2-formylacetic ester derivative, and thereafter, stereospecifically reducing the formyl group of the derivative by use of an enzymatic source capable of stereoselectively reducing the formyl group of the derivative.
Stereochemical Studies. LX. Neighboring Phenyl Group Participation. I. Stereospecific Transformation of L-Phenylalanine to Optically Active Tropic Acid
Juang, Tzuoh Miin,Yamada, Shun-ichi
, p. 4426 - 4430 (2007/10/02)
Trifluoroacetolysis of (S)-3-phenyllactic acid ester sulfonate((S)-7), obtained from L-phenylalanine via nitrous acid deamination followed by ethanolysis, afforded (R)-tropic acid ester((R)-8) in good yield by phenyl migration with inversion, while acetol
