87888-91-3

Upstream product

• 69369-05-7 9-(RS)-(2,3-dihydroxypropyl)-8-hydroxyadenine 
• 98-59-9 p-toluenesulfonyl chloride 
• 716-17-6 9-(2,3-dihydroxypropyl)adenine 
• 87888-82-2 2',3'-O-isopropylidene-9-(RS)-(2,3-dihydroxypropyl)-8-bromoadenine 
• 87888-87-7 2',3'-O-isopropylidene-9-(RS)-(2,3-dihydroxypropyl)-8-hydroxyadenine 
• 69369-04-6 9-(RS)-(2,3-dihydroxypropyl)-8-bromoadenine 
• 87935-99-7 9-1-(dihydroxypropyl-2',3'-O-isopropyliden)adenine 

Relevant academic research and scientific papers

PREPARATION OF ISOMERIC 3-AMINOPROPYLAMINO DERIVATIVES OF 9-(RS)-(2,3-DIHYDROXYPROPYL)ADENINE

Treatment of 9-(RS)-(2,3-dihydroxypropyl)adenine (III) with bromine in water afforded the 8-bromo derivative IV which on reaction with acetone was converted into the 1,3-dioxolane derivative VI.Reaction of compound VI with 1,3-diaminopropane, followed by acid hydrolysis, gave 9-(R,S)-(2,3-dihydroxypropyl)-8-(3-aminopropylamino)adenine (VIII).Compound IV reacts with 1,3-diaminopropane under formation of a mixture of compound VIII and isomeric 9-(RS)--8-hydroxyadenines (IX,X). 9-(R,S)-(2,3-Dihydroxypropyl)-8-hydroxyadenine (XVII) was prepared by reaction of compound VI with sodium benzoxide in dimethylformamide and subsequent acid hydrolysis.Its tosylation, followed by reaction of the obtained 3'-O-p-toluenesulfonyl derivative XVIII with 1,3-diaminopropane, furnished also the compound IX.In an analogous way, 9-(RS)-adenine (XXI) was prepared from the 3'-O-p-toluenesulfonyl derivative of compound III (XX).