878890-10-9

Usage

Uses

Used in Pharmaceutical Industry:
5-bromo-N,4-dimethyl-1,3-thiazol-2-amine(SALTDATA: FREE) is used as a building block for the synthesis of various pharmaceuticals. Its antimicrobial and antitumor properties make it a valuable component in the development of new drugs for treating infections and cancer.
Used in Agricultural Chemical Industry:
In the agricultural chemical industry, 5-bromo-N,4-dimethyl-1,3-thiazol-2-amine(SALTDATA: FREE) is used as a building block for the synthesis of agrochemicals. Its antimicrobial properties can be utilized in the development of pesticides and other products to protect crops from diseases and pests.
Used in Chemical Research and Drug Discovery:
5-bromo-N,4-dimethyl-1,3-thiazol-2-amine(SALTDATA: FREE) is commonly used as a reagent in chemical research and drug discovery. Its unique structure and properties make it a valuable tool for scientists to explore new chemical reactions and synthesize novel compounds with potential therapeutic applications.
Used in Scientific and Industrial Applications:
As a free chemical listed in the SALTDATA database, 5-bromo-N,4-dimethyl-1,3-thiazol-2-amine(SALTDATA: FREE) is available for use in various scientific and industrial applications. Its versatility and potential for use in multiple industries make it a valuable resource for researchers and manufacturers alike.

Upstream product

• 2161-68-4 N,4-dimethyl-1,3-thiazol-2-amine 

Downstream Products

• 1421693-22-2 3-(5-fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-ylamino)benzene sulfonamide 

Relevant academic research and scientific papers

Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents

Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the conserved ATP binding site, designing selective CDK9 inhibitors has been challenging. Here we report our continued efforts in the optimization of 2,4,5-tri-substituted pyrimidine compounds as potent and selective CDK9 inhibitors. The most selective compound 30m was >100-fold selective for CDK9 over CDK1 and CDK2. These compounds showed broad anti-proliferative activities in various solid tumour cell lines and patient-derived chronic lymphocytic leukaemia (CLL) cells. Decreased phosphorylation of the carboxyl terminal domain (CTD) of RNAPII at Ser-2 and down-regulation of anti-apoptotic protein Mcl-1 were confirmed in both the ovarian cancer model A2780 and patient-derived CLL cells.

A method for preparing such CDK inhibitors (by machine translation)

The invention discloses a method for preparing such CDK inhibitors, will be single-methyl thiourea and 1 - N monochloride reaction, 4 - dimethylthiazole - 2 - amine, by bromo reaction to obtain 5 - bromo - N, 4 - dimethylthiazole - 2 - amine, under the action of the catalyst after the with the borate to obtain aromatic borate intermediates; aromatic borate ester intermediate with 2, 4 - dichloro - 5 fluoro uracil in the noble metal catalytic under suzuki coupling reaction to obtain the coupling product to continue after the Buchwald - Hartwig with the aromatic amine in the reaction, ultimately to obtain the target product. (by machine translation)