878905-16-9

Basic information

• Product Name: N-(9-fluorenylmethoxycarbonyl)-5,5-difluoro-L-norleucine
• CAS NO: 878905-16-9
• Molecular Weight: 389.399
• Mol File: 878905-16-9.mol

Chemical Properties

• CAS DataBase Reference: N-(9-fluorenylmethoxycarbonyl)-5,5-difluoro-L-norleucine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(9-fluorenylmethoxycarbonyl)-5,5-difluoro-L-norleucine(878905-16-9)
• EPA Substance Registry System: N-(9-fluorenylmethoxycarbonyl)-5,5-difluoro-L-norleucine(878905-16-9)

Safety Data

• Hazardous Substances Data: 878905-16-9(Hazardous Substances Data)

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 223526-25-8 (4S)-4-(2'-carboxyethyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 136904-77-3 (4S)-4-(2-methoxycarbonylethyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 878009-67-7 (+)-tert-butyl (4S)-2,2-dimethyl-4-[(E)-3-oxobut-1-en-1-yl]-1,3-oxazolidine-3-carboxylate 
• 878009-69-9 (S)-tert-butyl 4-(3,3-difluorobutyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 878009-71-3 N-tert-butoxycarbonyl-5,5-difluoro-L-norleucine 
• 878009-68-8 (+)-tert-butyl (4S)-2,2-dimethyl-4-(3-oxobutyl)-1,3-oxazolidine-3-carboxylate 
• 878009-70-2 (S)-2-(N-tert-butyloxycarbonyl)amino-5,5-difluorohexan-1-ol 

Relevant articles and documents

Facile synthesis of (s)-5,5-difluoronorleucine and its incorporation in biologically active peptides as an methionine mimetic

Both Boc and Fmoc protected 5,5-difluoronorleucines (F2Nle) were easily prepared from commercially available amino acid derivatives. F2Nle can be viewed as a mimic of methionine in which the sulfur atom is replaced by the CF2 moiety. Two analogues of methionine-containing biologically active peptides (fMLP and Met-enkephalin) were prepared. The validity of CF2-substituted methionine analogues was confirmed in their biological assay.