878985-76-3Relevant academic research and scientific papers
Catalytic enantioselective synthesis of chiral isatin derivatives by an aldol approach
Yanagisawa, Akira,Kushihara, Naoyuki,Sugita, Takuya,Yoshida, Kazuhiro
, p. 1783 - 1788 (2012)
A catalytic enantioselective aldol reaction of alkenyl esters with isatins was achieved using an (S)-BINOL-derived chiral tin dibromide possessing a 4-tert-butylphenyl group at 3- and 3-positions as the chiral pre-catalyst in the presence of sodium methoxide and methanol. Optically active 3-alkylated 3-hydroxy-2-oxindoles having up to 98% ee were diastereoselectively obtained in high yields not only from cyclic alkenyl esters but also from acyclic ones under the influence of the in situ generated chiral tin bromide methoxide.
