879014-51-4Relevant articles and documents
Novel endotoxin-sequestering compounds with terephthalaldehyde-bis- guanylhydrazone scaffolds
Khownium, Kriangsak,Wood, Stewart J.,Miller, Kelly A.,Balakrishna, Rajalakshmi,Nguyen, Thuan B.,Kimbrell, Matthew R.,Georg, Gunda I.,David, Sunil A.
, p. 1305 - 1308 (2007/10/03)
We have shown that lipopolyamines bind to the lipid A moiety of lipopolysaccharide, a constituent of Gram-negative bacterial membranes, and neutralize its toxicity in animal models of endotoxic shock. In an effort to identify non-polyamine scaffolds with