87905-88-2Relevant articles and documents
Methoxymethylation of substituted alcohols using dimethoxymethane over Mo(VI)/ZrO2
Shyamsundar,Mohamed Shamshuddin,Ananda,Pratap
, p. 655 - 660 (2018/02/09)
The methoxymethylation reaction of alcohols was studied on Mo/ZrO2 (MZ) catalysts. The catalyst containing 5, 10 and 15 % Mo(VI) ions was prepared by solution combustion method. These solid acid catalytic materials were characterized by NH3- TPD, powder XRD, BET, FTIR spectroscopy, scanning electron microscopy, transmission electron spectroscopy and ICP- OES techniques. These catalysts were evaluated for their catalytic activity in the synthesis of methoxymethylation reactions of various substituted alcohols with dimethoxymethane in shorter reaction times (20 min) at moderate temperature (40 °C) with excellent yields (around 99 %). The main features of the Mo/ZrO2 catalyzed reaction are high yields, ease of scale up to gram scale, recyclable catalysts, inexpensive reagents, ecofriendly catalysts and a solvent free approach for the synthesis of methoxymethylated products.
Pyranodipyridine Compound
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Paragraph 0196-0199, (2017/06/12)
Compounds represented by formulae (I) to (XXII) or pharmaceutically acceptable salts thereof:
INHIBITORS OF THE KYNURENINE PATHWAY
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, (2014/12/12)
The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and phannaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.
New syntheses of orelline and analogues via metalation and cross-coupling reactions
Mongin, Florence,Trécourt, Fran?ois,Mongin, Olivier,Quéguiner, Guy
, p. 309 - 314 (2007/10/03)
New total syntheses of orelline and some analogues are reported. The methodology involves metalation of 3-alkoxy-2-iodopyridines to afford 3,4-dialkoxy-2-iodopyridines, on which cross-coupling reactions are performed to reach the 2,2′-bipyridine skeleton of the alkaloid.
Synthesis and Properties of 2,2'-Bipyridin-3-ols and -3,3'-diols
Siemanowski, Werner,Witzel, Herbert
, p. 1731 - 1739 (2007/10/02)
The synthesis of the 2-furyl ketones 5-7 and 13 and their reaction with ammonium acetate in boiling acetic acid to 3-substituted 2,2'-bipyridines and to 2-(2-pyrimidinyl)-3-pyridinol (14) via a ring-transformation reaction are described.Strong intramolecular hydrogen bonds are responsible for their physical and chemical properties.
REGIOSELECTIVE METALLATIONS OF (METHOXYMETHOXY)ARENES
Ronald, Robert C.,Winkle, Mark R.
, p. 2031 - 2042 (2007/10/02)
The methoxymethoxy substituent when attached to an aromatic ring functions as a moderately strong ortho-directing group in hydrogen-metal exchenge reactions.In many cases the propensity of the methoxymethoxylated arene toward ring metallations is greatly enhanced with concomitant suppression of undesirable side reactions such as nucleophilic attack and addition of metallating species.Unlike many other ortho-directing groups, the regio-direction of the methoxymethoxy substituent when in conjunction with other weaker directing groups is dependent upon the metallating medium.Thus, by changing the electron donating capacity of the metallating medium it is possible to selectively direct metallation to either of the positions ortho to the methoxymethoxy substituent.
