879083-87-1Relevant academic research and scientific papers
New chelating ligands with potential for pharmaceutical applications
Hamada, Yahia Z.,Harris, Wesley R.
, p. 45 - 50 (2010)
2-hydroxybenzylaminomethylphosphonic acid (HBAMPA) has been synthesized from commercially available chemicals and its aqueous coordination chemistry involving Al3+, Ga3+ and Fe3+ is described. At 25C and 0.1 M ionic strength KNO3, both Al3+and Ga3+ formed dinuclear complexes while Fe3+ formed the simple 1:1 complex (FeL) along with a mono-protonated complex (FeLH). HBAMPA formed neutral complexes with these trivalent metal ions, which lead to an early precipitation. The solution mixtures precipitated at pH 6.0 for Al3+, pH 4.0 for Fe3+, and pH 3.0 for the Ga3+ ion. The carboxylic acid analogue of HBAMPA, 2-hydroxybenzylalanine (HBA) also has been tested with Al3+ and Fe3+. It appeared that HBA solubilized the Al3+ ion at pH 7.4. However, the Fe3+-HBA solution mixture formed a complex of a very minimum solubility and an early pH precipitation prevailed. HBA and HBAMPA are multi-dentate, phenol-containing ligands capable of binding a variety of metal ions with very high stability constants. These stability constants are discussed. Copyright Taylor & Francis Group, LLC.
