879222-36-3

Upstream product

• 879222-35-2 7-hydroxy-2-methylsulfanyl-thiazolo[4,5-b]pyridine-6-carboxylic acid tert-butylamide 
• 879222-33-0 3-(4-amino-2-methylsulfanyl-thiazol-5-yl)-2-cyano-3-oxo-propionic acid tert-butyl ester 
• 879222-30-7 3-(4-amino-2-methylsulfanyl-thiazol-5-yl)-N-tert-butyl-3-oxo-propionamide 
• 879222-31-8 7-hydroxy-2-methylsulfanyl-thiazolo[4,5-b]pyridine-6-carbonitrile 
• 879222-32-9 7-chloro-2-methylsulfanyl-thiazolo[4,5-b]pyridine-6-carbonitrile 
• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 879222-37-4 7-(3-chloro-4-fluoro-phenylamino)-2-methanesulfinyl-thiazolo[4,5-b]pyridine-6-carbonitrile 
• 879222-69-2 7-(3-chloro-4-fluoro-phenylamino)-2-(6-methoxy-pyridin-3-ylamino)-thiazolo[4,5-b]pyridine-6-carbonitrile 

Relevant academic research and scientific papers

A concise synthesis of 7-chloro-2-methylsulfanyl-thiazolo[4,5-b]pyridine-6-carbonitrile, a versatile intermediate for substituted 6-cyanothiazolopyridines

We describe the development of a simple route for the preparation of the novel title intermediate thiazolo[4,5-b]pyridine. This intermediate was particularly well suited for derivatization at the C-2 and C-7 positions of the bicyclic ring system.

Thiazolopyridine kinase inhibitors

The present invention is directed to novel thiazolopyridines, pharmaceutical compositions thereof, and the use thereof as inhibitors of ATP-protein kinase interactions. The thiazolopyridine compounds have the following Formula (I):