879274-73-4Relevant academic research and scientific papers
“On-water” synthesis of quinazolinones and dihydroquinazolinones starting from O-bromobenzonitrile
Liu, Zibin,Zeng, Li-Yan,Li, Chao,Yang, Fubiao,Qiu, Fensheng,Liu, Shuwen,Xi, Baomin
, (2018)
A versatile and practical “on-water” protocol was newly developed to synthesize quinazolinones using o-bromobenzonitrile as a novel starting material. Studies have found that air as well as water plays an important role in synthesis of quinazolinones. Further investigation indicated that dihydroquinazolinones can be prepared with this protocol under the protection of N2. The protocol can be extended to other substrates and various quinazolinones and dihydroquinazolinones were obtained. o-Bromobenzamide, o-aminobenzonitrile, and o-aminobenzamide were also evaluated as starting materials, and the results further proved the versatility of this protocol, especially towards dihydroquinazolinones.
QUINAZOLINES USEFUL AS MODULATORS OF VOLTAGE GATED ION CHANNELS
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Page/Page column 40, (2008/12/06)
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS
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Page/Page column 114-115, (2008/06/13)
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
