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Angiotensin II, Cys(1,8)- is a synthetic analog of the naturally occurring peptide hormone angiotensin II, which plays a crucial role in regulating blood pressure and fluid balance in the body. This modified version of angiotensin II has a cysteine residue at positions 1 and 8, which allows for the formation of a disulfide bridge, enhancing the stability and bioactivity of the molecule. The Cys(1,8)- modification is designed to improve the resistance to degradation by enzymes, thereby prolonging its action in the body. This chemical modification can be particularly useful in pharmaceutical applications, as it may lead to more effective drugs with longer-lasting effects. Angiotensin II, Cys(1,8)-, like its natural counterpart, can bind to angiotensin receptors, leading to vasoconstriction and the release of aldosterone, which in turn increases sodium and water reabsorption in the kidneys, ultimately raising blood pressure.

87937-69-7

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87937-69-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 87937-69-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,9,3 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 87937-69:
(7*8)+(6*7)+(5*9)+(4*3)+(3*7)+(2*6)+(1*9)=197
197 % 10 = 7
So 87937-69-7 is a valid CAS Registry Number.

87937-69-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name <Cys1,8>angiotensin II

1.2 Other means of identification

Product number -
Other names (Cys1,8)angiotensin II

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:87937-69-7 SDS

87937-69-7Upstream product

87937-69-7Downstream Products

87937-69-7Relevant academic research and scientific papers

A Cyclic Angiotensin Antagonist: angiotensin II

Matsoukas, John M.,Scanlon, Martin N.,Moore, Graham J.

, p. 404 - 406 (2007/10/02)

1,8>angiotensin II has been synthesized by the solid-phase method and purified by carboxymethylcellulose chromatography and reversed-phase HPLC.Treatment of this peptide with iodine gave the cyclic octapeptide 1,8>angiotensin II, which was isolated by Sephadex G-25 chromatography and reversed-phase HPLC.Comparison of the circular dichroism spectra of the open-chain and cyclic peptides, respectively, demonstrated the existence of a disulfide bond with right-handed chirality in the cyclic peptide.In the isolated rat uterus assay, theopen-chain peptide was found to be a potent antagonist of angiotensin II, having approximately 10percent of the activity of 1,Ile8>angiotensin II, and the cyclic peptide had about 10percent of the antagonist potency of its open-chain synthetic precursor.

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