879375-64-1

Upstream product

• 769929-31-9 carbonic acid (E)-4-[(benzyl)(1H-indol-2-ylmethyl)amino]-but-2-enyl methyl ester 
• 879375-61-8 carbonic acid 4-[benzyl-(1H-indol-3-ylmethyl)-amino]-but-2-enyl ester methyl ester 
• 57506-64-6 N-(1H-indol-3-ylmethyl)-N-benzylamine 
• 149685-64-3 N-((1H-indol-2-yl)methyl)-1-phenylmethanamine 
• 1629159-11-0 C₂₂H₂₄N₂O₃ 
• 19005-93-7 1H-indol-2-ylcarboxaldehyde 
• 879375-54-9 acetic acid 4-[benzyl-(1H-indol-2-ylmethyl)-amino]-but-2-enyl ester 
• 769929-49-9 (E)-4-[(benzyl)(1H-indol-2-ylmethyl)amino]-but-2-enoic acid ethyl ester 
• 769929-51-3 (E)-4-[(benzyl)(1H-indol-2-ylmethyl)amino]-but-2-en-1-ol 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

N-aryl of containing compound chiral phosphine nitrogen, synthetic method and application

The invention provides a chirality phosphine nitrogen compound containing N-aryl as well as a synthetic method and application thereof. The phosphine nitrogen compound is based on axial chirality or comprises a helical chirality skeleton, and is synthetiz

Ruthenium-catalyzed intramolecular allylic dearomatization/migration reaction of indoles and pyrroles

An efficient synthesis of polycyclic indole and pyrrole derivatives via a ruthenium-catalyzed intramolecular allylic dearomatization/migration reaction has been developed. This method features wide substrate scope, mild reaction conditions, and an operationally simple procedure. The capture of the spiro intermediate provides solid evidence for the dearomatization/migration reaction pathway.

Highly enantioselective synthesis of tetrahydrocarbolines via iridium-catalyzed intramolecular friedel-crafts type allylic alkylation reactions

A highly enantioselective synthesis of substituted tetrahydrocarbolines via Ir-catalyzed Friedel-Crafts type intramolecular asymmetric allylic alkylation of 2-indolyl allyl carbonates has been developed. This strategy features excellent chemoselectivity a

Enantioselective functionalization of indoles and pyrroles via an in situ-formed spiro intermediate

Herein we report a highly enantioselective synthesis of polycyclic indoles and pyrroles with up to 99% ee by an iridium catalyst system consisting of a commercially available iridium precursor and a readily accessible ligand. Investigation of the reaction mechanism led to the discovery of an unprecedented dearomatized spiro intermediate and its in situ migration phenomenon. The new reaction mode features switching of the substituent from the indole C-3 position to the C-2 position (from the C-2 position to the C-3 position in the case of pyrrole) without loss of the enantiomeric purity, providing a novel concept in designing the asymmetric construction of enantiopure polycyclic indoles and pyrroles.

Highly enantioselective synthesis of tetrahydro-β-carbolines and tetrahydro-γ-carbolines via Pd-catalyzed intramolecular allylic alkylation

A novel Pd-catalyzed intramolecular allylic alkylation of indoles allows THBCs and THGCs to be effectively synthesized in high yields and excellent enantiomeric excesses (ee up to 97%). Copyright