879486-90-5

Usage

Molecular Structure

A piperazine ring with a carboxamide group attached to a phenyl ring, which is connected to a 1,3,2-dioxaborolan group.

Use

Laboratory research

Mechanism of Action

Potent inhibitor of IKKβ, a key regulator of the NF-κB pathway

Role in Disease

Plays a critical role in inflammation and immune response

Therapeutic Potential

Studied for its potential effects in various diseases, including cancer, inflammatory bowel disease, and rheumatoid arthritis

Properties

Anti-inflammatory and antitumor

Importance

Valuable tool for scientific research and potential drug development.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 957198-19-5 C₁₉H₂₁BN₂O₆ 
• 756520-47-5 phenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate 

Relevant academic research and scientific papers

SUBSTITUTED BIPHENYL DERIVATIVE

The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C6-C10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C1-C6 alkyl)amino group, a di-(C1-C6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C1-C6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R3 represents a C1-C6 alkyl group, and so on; and R4 represents a C1-C6 alkyl group, and so on.

AMINOHETEROARYL COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS

Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.