879499-34-0Relevant academic research and scientific papers
A simple approach for the regioselective synthesis of imidazo[1,2-a] pyrimidiones and pyrimido[1,2-a]pyrimidinones
Font, David,Linden, Anthony,Heras, Montserrat,Villalgordo, José M.
, p. 1433 - 1443 (2006)
Several imidazo and pyrimido[1,2-a]pyrimidinones of type 1 and 2 were synthesized through intramolecular cyclization of pyrimidines 9 or pyrimidinones 10 bearing a variety of β and γ-aminoalcohols at the 2-position. Ring closure of the pyrimidinones of type 10 under Mitsunobu conditions lead to mixtures of both bicyclic regioisomers 1 and 2. Treatment of pyrimidines of type 9 with H2SO4 provided an efficient and operationally simple one-pot hydrolysis-cyclization procedure for obtaining imidazo and pyrimido[1,2-a]pyrimidinones 1 in good yields as the sole regioisomeric bicyclic product.
