879551-17-4Relevant articles and documents
Solid-phase synthesis and configurational reassigment of callipeltin E. Implications for the structures of callipeltins A and B
Calimsiz, Selcuk,Ramos, Angel I. Morales,Lipton, Mark A.
, p. 6351 - 6356 (2006)
Two possible isomers of the natural product callipeltin E (1, 5) were synthesized by using an Fmoc-based solid-phase strategy in 7 steps, in 20% and 26% overall yields, respectively. The 1H NMR spectrum of synthetic 5 correlated closely with that of the natural product, whereas that of 1 did not, providing confirmation of the configurational reassignment of the N-terminal residue of callipeltin E as D-allothreonine. This result strongly implies that the corresponding residue in the closely related cyclic depsipeptides callipeltins A and B should also be considered a D-allothreonine residue.
