879562-21-7 Usage
Chemical class
Sulfonyl chlorides
Explanation
Different sources of media describe the Explanation of 879562-21-7 differently. You can refer to the following data:
1. 1-CYCLOPROPANECARBONYL-2,3-DIHYDRO-1H-INDOLE-5-SULFONYL CHLORIDE belongs to the class of sulfonyl chlorides, which are important in drug synthesis and medicinal chemistry.
2. Cyclopropanecarbonyl group
2. The compound contains a cyclopropanecarbonyl group, which contributes to the diversity and complexity of synthesized molecules and is important in drug discovery and development.
3. Dihydroindole ring
3. The presence of a dihydroindole ring in the compound adds structural complexity and can be crucial for the activity of the synthesized molecules.
4. Sulfonamide group
4. The sulfonamide group in the compound allows for the formation of amide and urea derivatives, which are often used to modify the biological activity and pharmacokinetic properties of potential drug candidates.
5. Pharmaceutical industry application
5. 1-CYCLOPROPANECARBONYL-2,3-DIHYDRO-1H-INDOLE-5-SULFONYL CHLORIDE is commonly used as a building block in the synthesis of various biologically active molecules, such as potential drug candidates and agrochemicals.
6. Value in drug discovery
6. The compound's unique structure and functional groups make it a valuable intermediate in drug discovery and development, as it can lead to the synthesis of diverse and biologically active molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 879562-21-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,9,5,6 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 879562-21:
(8*8)+(7*7)+(6*9)+(5*5)+(4*6)+(3*2)+(2*2)+(1*1)=227
227 % 10 = 7
So 879562-21-7 is a valid CAS Registry Number.
879562-21-7Relevant articles and documents
Identification of inhibitors of NOD1-induced nuclear factor-κB activation
Khan, Pasha M.,Correa, Ricardo G.,Divlianska, Daniela B.,Peddibhotla, Satyamaheshwar,Sessions, E. Hampton,Magnuson, Gavin,Brown, Brock,Suyama, Eigo,Yuan, Hongbin,Mangravita-Novo, Arianna,Vicchiarelli, Michael,Su, Ying,Vasile, Stefan,Smith, Layton H.,Diaz, Paul W.,Reed, John C.,Roth, Gregory P.
experimental part, p. 780 - 785 (2011/12/02)
NOD1 (nucleotide-binding oligomerization domain 1) protein is a member of the NLR (NACHT and leucine rich repeat domain containing proteins) protein family, which plays a key role in innate immunity as a sensor of specific microbial components derived from bacterial peptidoglycans and induction of inflammatory responses. Mutations in NOD proteins have been associated with various inflammatory diseases that affect NF-κB (nuclear factor κB) activity, a major signaling pathway involved in apoptosis, inflammation, and immune response. A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Molecular Libraries Probe Production Center Network program to identify the active scaffolds. Herein, we report the chemical synthesis, structure-activity relationship studies, downstream counterscreens, secondary assay data, and pharmacological profiling of the 2-aminobenzimidazole lead (compound 1c, ML130) as a potent and selective inhibitor of NOD1-induced NF-κB activation.
