87964-82-7

Basic information

• Product Name: 5-chloro-2,3-dimethoxybenzoyl chloride
• Synonyms: 5-chloro-2,3-dimethoxybenzoyl chloride
• CAS NO: 87964-82-7
• Molecular Weight: 235.067
• Mol File: 87964-82-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-2,3-dimethoxybenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2,3-dimethoxybenzoyl chloride(87964-82-7)
• EPA Substance Registry System: 5-chloro-2,3-dimethoxybenzoyl chloride(87964-82-7)

Safety Data

• Hazardous Substances Data: 87964-82-7(Hazardous Substances Data)

Upstream product

• 107189-00-4 2-(5-Bromo-2,3-dimethoxyphenyl)-4,5-dihydro-4,4-dimethyloxazole 
• 107189-03-7 2-(5-Chloro-2,3-dimethoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 129117-51-7 5-Bromo-N-(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxybenzamid 
• 107188-91-0 5-bromo-2,3-dimethoxybenzoic acid chloride 
• 72517-23-8 5-bromo-2,3-dimethoxybenzoic acid 
• 86232-26-0 3-methoxy-2-hydroxy-5-chlorotoluene 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 86232-27-1 3-methyl-5-chloro-1,2-dimethoxybenzene 
• 86232-53-3 3-Methyl-4,5-dimethoxyaniline 
• 86232-28-2 5-chloro-2,3-dimethoxybenzaldehyde 
• 7740-05-8 5-chloro-2-hydroxy-3-methoxy-benzaldehyde 
• 72517-22-7 5-chloro-2,3-dimethoxybenzoic acid 

Downstream Products

• 107188-78-3 5-Chloro-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dimethoxy-benzamide 
• 86232-47-5 5-chloro-2,3-dihydroxyphenylacetic acid 
• 86232-49-7 methyl 5-chloro-2,3-dihydroxyphenylacetate 
• 86232-39-5 5-chloro-2,3-dimethoxyphenylacetic acid 
• 86232-43-1 methyl 5-chloro-2,3-dimethoxyphenylacetate 
• 86232-45-3 5-chloro-2,3-dimethoxyphenylacetohydroxamic acid 
• 86232-50-0 methyl 2,3-diacetoxy-5-chlorophenylacetate 
• 86232-51-1 2,3-diacetoxy-5-chlorophenylacetic acid 
• 86232-41-9 5-chloro-2,3-dimethoxydiazoacetophenone 

Relevant articles and documents

Synthesis and 5-HT-3 receptor binding activity of 5-[125I]iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl]benzamide and its 5-halogen-2-alkoxyl homologues

(S)-5-Iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (MIZAC) was prepared from 5-iodo-2,3-dimethoxybenzoyl chloride and (S)-3-aminoquinuclidine. [125I]Iodode-stannylation of its corresponding 5-tri-n-butyltin derivative gave [125I]-MIZAC at 1800 Ci/mmol. Binding of [125I]-MIZAC in rat entorhinal cortex revealed a K(D) of 1.37 ± 0.21 nM. A series of racemic 2-O-alkyl derivatives of MIZAC were prepared and 5-HT-3 receptor affinities were determined by inhibition of [125I]-MIZAC binding. Optimal affinity for the receptor was obtained with small, electron-withdrawing substituents in the aromatic 5-position and with bulky substituents in the 3-position. [125I]-MIZAC is a selective radioligand useful for in vitro identification of the 5-HT-3 receptor.

SYNTHESIS OF 5-HALOGEN-SUBSTITUTED 2,3-DIHYDROXYPHENYLACETIC ACIDS, THEIR ESTERS, AND 2,3-DIMETHOXYPHENYLACETOHYDROXAMIC ACIDS

Many-stage general methods were developed for the synthesis of 5-bromo- or 5-chloro-substituted 2,3-dimethoxyphenylacetic acids from o-vanilin.Methods were also developed for their conversion into the corresponding hydroxamic acids, 2,3-dihydroxyphenylace