87974-49-0

Upstream product

• 635-93-8 5-chlorosalicyclaldehyde 

Downstream Products

• 13589-72-5 5-chloro-2-hydroxybenzonitrile 
• 635-93-8 5-chlorosalicyclaldehyde 
• 75551-87-0 2-Aminomethyl-4-chloro-6-iodo-phenol; hydrochloride 
• 72973-49-0 6-chlorocoumarin-3-carboxylic acid 
• 3970-05-6 5-chloro-2-hydroxybenzylamine 

Relevant academic research and scientific papers

A reusable test paper based on a simple salicylaldehyde derivate for the real-time detection of phosgene in gas phase

Phosgene is an important organic activity intermediate as well as a poisonous gas. However, the widespread use and abuse of phosphene brings potential risks to public safety. So it is very important to detect phosgene quickly and reliably. Up to now, a lo

Synthesis and cytotoxic evaluation of undecenoic acid-based oxime esters

A series of undecenoic acid-based aldoxime esters have been synthesized using various substituted benzaldehydes and undecenoic acid. These oxime esters have been evaluated for their cytotoxic activities against HeLa, B16-F10, SKOV3, MCF7 and CHO-K1 normal cell line using MTT assay. Most of the synthesized compounds exhibit cytotoxicity. Particularly, 2,3-dimethoxy (IC50 value 12.48μM) and 3-methoxy (IC50 value 13.58μM) derivatives exhibit promising activities against SKOV3 cell lines. All the synthesized compounds are non-toxic towards the Chinese hamster ovary (CHO-K1) normal cell line.

Preparation method of piperidine compound

The invention discloses a preparation method of a piperidine compound 4-((2-(aminomethyl)-4-bromophenoxy) methyl) piperidine-1-tert-butyl formate. 5-chloro-2-hydroxybenzaldehyde is used as a starting material and subjected to oximation, elimination, ether

Chromatography-free entry to substituted salicylonitriles: Mitsunobu-triggered domino reactions of salicylaldoximes

A mild and efficient one-pot procedure is described to transform salicylaldoximes into salicylonitriles using Mitsunobu chemistry. The reactions proceed through the corresponding 1,2-benzisoxazoles that undergo the Kemp elimination in situ to generate the

Modulation of imprinting efficiency in nanogels with catalytic activity in the Kemp elimination

The interactions between the template and the functional monomer are a key to the formation of cavities in the imprinted nanogels with high molecular recognition properties. Nanogels with enzyme-like activity for the Kemp elimination have been synthesized

Cytokinin receptor antagonists derived from 6-benzylaminopurine

Recently we reported 6-(2-hydroxy-3-methylbenzylamino)purine (PI-55) as the first molecule to antagonize cytokinin activity at the receptor level. Here we report the synthesis and in vitro biological testing of eleven BAP derivatives substituted in the be

Characterization of scavengers of γ-ketoaldehydes that do not inhibit prostaglandin biosynthesis

Expression of cyclooxygenase-2 (COX-2) is associated with the development of many pathologic conditions. The product of COX-2, prostaglandin H2 (PGH2), can spontaneously rearrange to form reactive γ-ketoaldehydes called levuglandins (LGs). This γ-ketoaldehyde structure confers a high degree of reactivity on the LGs, which rapidly form covalent adducts with primary amines of protein residues. Formation of LG adducts of proteins has been demonstrated in pathologic conditions (e.g., increased levels in the hippocampus in Alzheimer's disease) and during physiologic function (platelet activation). On the basis of knowledge that lipid modification of proteins is known to cause their translocation and to alter their function, we hypothesize that modification of proteins by LG could have functional consequences. Testing this hypothesis requires an experimental approach that discriminates between the effects of protein modification by LG and the effects of cyclooxygenase-derived prostanoids acting through their G-protein coupled receptors. To achieve this goal, we have synthesized and evaluated a series of scavengers that react with LG with a potency more than 2 orders of magnitude greater than that with the ε-amine of lysine. A subset of these scavengers are shown to block the formation of LG adducts of proteins in cells without inhibiting the catalytic activity of the cyclooxygenases. Ten of these selective scavengers did not produce cytotoxicity. These results demonstrate that small molecules can scavenge LGs in cells without interfering with the formation of prostaglandins. They also provide a working hypothesis for the development of pharmacologic agents that could be used in experimental animals in vivo to assess the pathophysiological contribution of levuglandins in diseases associated with cyclooxygenase up-regulation.

Inhibition of monoamine oxidases by coumarin-3-acyl derivatives: Biological activity and computational study

A series of coumarin-3-acyl derivatives have been synthesized and investigated for the ability to inhibit selectively monoamine oxidases. The coumarin-3-carboxylic acids, 2a-e, proved to be reversible and selective inhibitors of the MAO-B isoform, display

SUBSTITUTED PYRIMIDINES

The invention relates to novel substituted pyrimidines of formula (I), in which R1, R2, R3, R4, Q, X and n have the meanings as cited in the description. The invention also relates to a method and intermediate products for producing these pyrimidines, and to the use thereof as plant control agents, particularly as herbicides.

NMR spectral assignment of substituted salicylaldoximes by inverse pulse techniques with z-gradient selection: Correlation of NMR parameters with substituent constants

1H and 13C and also 1H,13C HMQC and 1H,X HMBC (X = 13C and 15N) correlation maps with z-gradient selection of seven salicylaldoximes were recorded and assigned and their paramete