87979-85-9Relevant academic research and scientific papers
Magnolia extract, magnolol, and metabolites: Activation of cannabinoid CB2 receptors and blockade of the related GPR55
Rempel, Viktor,Fuchs, Alexander,Hinz, Sonja,Karcz, Tadeusz,Lehr, Matthias,Koetter, Uwe,Müller, Christa E.
supporting information, p. 41 - 45 (2013/03/13)
The bark of Magnolia officinalis is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. We found that the extract and its main bioactive constituents, magnolol and honokiol, can activate cannabinoid
Cytotoxic neolignans: An SAR study
Kong, Zwe-Ling,Tzeng, Shin-Cheng,Liu, Yeuk-Chuen
, p. 163 - 166 (2007/10/03)
The cytotoxic effects of different neolignans with the structure 1 were studied. The neolignans, magnolol 1 and honokiol 2 have been reported to inhibit the growth of several tumor cell lines in vitro and in vivo. The chemical structure of magnolol and honokiol consists of biphenyl skeleton with phenolic and allylic functionalities. Analogs of 1 and 2 containing different substitution have been studies for their effect on the growth of Hep-G2 and their structure-activity relationships were reported in this work.
