88-34-6

Basic information

• Product Name: [2,4-bis(1,1-dimethylpropyl)phenoxy]acetyl chloride
• Synonyms: [2,4-bis(1,1-dimethylpropyl)phenoxy]acetyl chloride;[2,4-bis(1,1-dimethylpropyl)phenoxy]-acetyl chlorid
• CAS NO: 88-34-6
• Molecular Formula: C₁₈H₂₇ClO₂
• Molecular Weight: 310.85878
• EINECS: 201-822-4
• Mol File: 88-34-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 366.4°C at 760 mmHg
• Flash Point: 135.1°C
• Appearance: /
• Density: 1.019g/cm³
• Vapor Pressure: 1.47E-05mmHg at 25°C
• Refractive Index: 1.492
• CAS DataBase Reference: [2,4-bis(1,1-dimethylpropyl)phenoxy]acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: [2,4-bis(1,1-dimethylpropyl)phenoxy]acetyl chloride(88-34-6)
• EPA Substance Registry System: [2,4-bis(1,1-dimethylpropyl)phenoxy]acetyl chloride(88-34-6)

Safety Data

• Hazardous Substances Data: 88-34-6(Hazardous Substances Data)

Usage

General Description

[2,4-bis(1,1-dimethylpropyl)phenoxy]acetyl chloride is a chemical compound that belongs to the class of acyl chlorides. It is characterized by the presence of a phenoxy group, which is attached to a central acetyl chloride molecule through two 1,1-dimethylpropyl substituents on the 2 and 4 positions of the phenoxy ring. [2,4-bis(1,1-dimethylpropyl)phenoxy]acetyl chloride is commonly used in organic synthesis as a reactive intermediate for the preparation of various pharmaceuticals, agrochemicals, and other organic compounds. It is important to handle and store [2,4-bis(1,1-dimethylpropyl)phenoxy]acetyl chloride with proper safety precautions due to its corrosive and hazardous nature.

InChI:InChI=1/C18H27ClO2/c1-7-17(3,4)13-9-10-15(21-12-16(19)20)14(11-13)18(5,6)8-2/h9-11H,7-8,12H2,1-6H3

Upstream product

• 120-95-6 2,4-di-tert-amylphenol 
• 13402-96-5 2-(2,4-di-t-amylphenoxy)acetic acid 

Downstream Products

• 71653-91-3 (2,4-di-tert-pentyl-phenoxy)-acetic acid-[3-(4-oxo-3-phenyl-2-phenylimino-thiazolidin-5-ylidenemethyl)-phenyl ester] 
• 116671-04-6 4-[2-(2,4-di-tert-pentyl-phenoxy)-acetylamino]-2-methoxy-1-(3-oxo-3-phenyl-propionylamino)-benzene 
• 116670-71-4 4-[2-(2,4-di-tert-pentyl-phenoxy)-acetylamino]-1-methoxy-2-(3-oxo-3-phenyl-propionylamino)-benzene 
• 103325-59-3 3-[2-(2,4-di-tert-pentyl-phenoxy)-acetylamino]-benzoic acid-(5-chloro-2-hydroxy-4-methyl-anilide) 
• 858816-51-0 1-[2-(2,4-di-tert-pentyl-phenoxy)-acetylamino]-4-[3-(2-methoxy-phenyl)-3-oxo-propionylamino]-benzene 
• 88870-07-9 5-Methoxy-4,4-dimethyl-3-oxo-pentanoic acid (5-{2-[2,4-bis-(1,1-dimethyl-propyl)-phenoxy]-acetylamino}-2-chloro-phenyl)-amide 
• 50670-86-5 α-Chlor-α-(2-brombenzoyl)-5-<α-(2,4-di-t-amylphenoxy)-acetylamino>-2-chloracetanilid 
• 50670-93-4 α-(2-Chlorbenzoyl)-α-brom-5-<α-(2,4-di-t-amylphenoxy)-acetylamino>-2-chloracetanilid 
• 50670-84-3 α-Chlor-α-(2-chlorbenzoyl)-5-<α-(2,4-di-t-amylphenoxy)-acetylamino>-2-chloracetanilid 
• 50671-01-7 α-(2-Chlorbenzoyl)-5-<α-(2,4-di-t-amylphenoxy)-acetylamino>-2-chloracetanilid 
• 50671-07-3 α-(2-Fluorbenzoyl)-5-<α-(2,4-di-t-amylphenoxy)-acetylamino>-2-chloracetanilid 
• 96774-03-7 4,4-Dimethyl-3-oxo-pentanoic acid (5-{2-[2,4-bis-(1,1-dimethyl-propyl)-phenoxy]-acetylamino}-2-chloro-phenyl)-amide 
• 50671-00-6 N-(3-amino-4-chlorophenyl)-2-(2,4-di-tert-pentylphenoxy)acetamide 
• 97691-99-1 2-Chloro-5-methoxy-4,4-dimethyl-3-oxo-pentanoic acid (5-{2-[2,4-bis-(1,1-dimethyl-propyl)-phenoxy]-acetylamino}-2-chloro-phenyl)-amide 

Relevant articles and documents

Process for producing aromatic amide compounds

There is disclosed a process for producing an aromatic amide compound of the general formula (4), including the steps of subjecting an o-nitrophenol compound of the general formula (1) to catalytic reduction in acetone or an aromatic hydrocarbon solvent under the presence of a nickel catalyst to give an o-aminophenol compound of the general formula (2); and (b) subjecting the o-aminophenol compound of the general formula (2) to condensation with an acid chloride compound having a sulfur content of 0.5% or less, based on the weight of the acid chloride compound, of the general formula (3) in acetone or an aromatic hydrocarbon solvent under an atmosphere of an inert gas having an oxygen concentration of 1% or less. The acid chloride compound having a sulfur content of 0.5% or less, based on the weight of the acid chloride compound, of the general formula (3) may be obtained by allowing a carboxylic acid compound of the general formula (5) to react with thionyl chloride and by concentrating the reaction mixture. Also disclosed is another process for producing an aromatic amide compound of the general formula (4), including the step of subjecting an o-aminophenol hydrochloride salt of the general formula (6) to condensation with an acid chloride compound having a sulfur content of 0.8% or less, based on the weight of the acid chloride compound, of the general formula (3) in an inert solvent.