88010-91-7Relevant academic research and scientific papers
Preparation and reactions of (1 H-tetrazol-5-yl)zinc pivalates
Tüllmann, Carl Phillip,Steiner, Sebastian,Knochel, Paul
, p. 2357 - 2363 (2020/08/19)
The preparation and reactivity of new solid heterocyclic organozinc reagents, namely N -protected (1 H -tetrazol-5-yl)zinc pivalates, as storable solids with appreciably air and moisture stability are reported. They are obtained in high yields from protected 1 H -tetrazoles by de-protonation using the mixed zinc-magnesium base TMPZnCl·Mg(OPiv) 2(abbreviated as TMPZnOPiv; TMP = 2,2,6,6-tetramethylpiperidyl). Subsequent cross-couplings and copper-catalyzed electrophilic aminations using hydroxylamine benzoates give access to functionalized 1 H -tetrazoles while tolerating many functional groups.
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MONOACYLGLYCEROL LIPASE (MAGL)
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Page/Page column 219, (2020/10/21)
The application relates to heterocyclic compounds of the general formula (I), compositions comprising such compounds, a process for preparing these compounds and their medical use. The compounds act as monoacylglycerol lipase (MAGL) inhibitors and are useful in the treatment of neuroinflammation, neurodegenerative diseases, pain, cancer or mental disorders.
Facile one-pot preparation of 5-aryltetrazoles and 3-arylisoxazoles from aryl bromides
Kobayashi, Eiji,Togo, Hideo
, p. 4226 - 4235 (2018/07/06)
The successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally diphenylphosphoryl azide provided efficiently the corresponding 5-aryltetrazoles in good to moderate yields. Similarly, the successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally diethyl acetylenedicarboxylate and Oxone provided efficiently the corresponding diethyl 3-arylisoxazole-4,5-dicarboxylates in good to moderate yields. Aromatic aldoximes are the key intermediates in both reactions, and 5-aryltetrazoles and 3-arylisoxazoles could be obtained from aryl bromides in one pot under transition-metal-free conditions.
Promoting near-infrared emission of neodymium complexes by tuning the singlet and triplet energy levels of β-diketonates
Yang, Lifen,Gong, Zeliang,Nie, Daobo,Lou, Bin,Bian, Zuqiang,Guan, Min,Huang, Chunhui,Lee, Hyun Joo,Baik, Woo Phil
, p. 791 - 796 (2007/10/03)
A series of neodymium complexes with various modified β-diketonates and their corresponding gadolinium complexes have been synthesized and characterized. The singlet and triplet energy levels of the coordinated ligands were measured and compared. These co
5-Aryltetrazole Compounds, compositions thereof, and uses therefor
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Page 30, (2008/06/13)
The present invention relates to 5-Aryltetrazole compounds, compositions comprising a 5-Aryltetrazole compound, and methods for treating an inflammation disease, a reperfusion disease, hyperuricemia, gout, or tumor-lysis syndrome in an animal in need ther
