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Usage

Uses

Used in Pharmaceutical Industry:
AKOS BB-7578 is used as an intermediate in the synthesis of various pharmaceutical compounds.
Used in Flavor and Fragrance Industry:
AKOS BB-7578 is used as a component in the production of flavors and fragrances.
Used in Organic Synthesis:
AKOS BB-7578 is used as a starting material for the synthesis of other organic compounds.
It is important to handle AKOS BB-7578 with proper safety precautions and in accordance with regulations for handling and storage of hazardous chemicals.

InChI:InChI=1/C12H9ClN2/c1-2-8-4-3-5-9-6-10(7-14)12(13)15-11(8)9/h3-6H,2H2,1H3

Upstream product

• 335196-05-9 2-chloro-8-ethyl-quinoline-3-carbaldehyde 

Downstream Products

• 1100051-09-9 8-ethyl-2-phenylethynyl-quinoline-3-carbonitrile 
• 1415354-70-9 2-(benzylamino)-8-ethylquinoline-3-carbonitrile 
• 1415354-63-0 1-benzyl-9-ethyl-1H-pyrimido[4,5-b]quinolin-4-one 

Relevant academic research and scientific papers

An alternate route to the synthesis of imidazo[1,2-a]quinolines using I2-NaI reagent

A new and a facile route to the synthesis of imidazo[1,2-a]quinolines has been described via iodocyclization reaction of 2-allylaminoquinoline derivatives using I2-NaI reagent.

Base-catalyzed cyclization reaction of 2-chloroquinoline-3-carbonitriles and guanidine hydrochloride: A rapid synthesis of 2-amino-3H-pyrimido[4,5-b] quinolin-4-ones

t-BuOK-catalyzed cyclization of 2-chloroquinoline-3-carbonitriles with guanidine hydrochloride provided simple and rapid synthesis of 2-amino-3H-pyrimido[4,5-b]quinolin-4-ones in very short reaction time with good yield. Other 1,3-binucleophiles are found to react at the same rate. This methodology could be extended with their 3-formyl and 3-ester derivatives for the synthesis of pyrimido annulated quinolines.

A one pot method of conversion of aldehydes into nitriles using iodine in ammonia water: Synthesis of 2-chloro-3-cyanoquinolines

One pot rapid transformations of heteroaromatic carbaldehyde to cyano group using cheap and easily available iodine in aqueous ammonia has been described.

Vilsmeier-Haack reagent: A facile synthesis of 2-chloro-3-formylquinolines from N-arylacetamides and transformation into different functionalities

A simple and regioselective synthesis of 2-chloro-3-formylquinolines through Vilsmeier-Haack cyclisation of N-arylacetamides has been reported. The cyclisation is facilitated by N-arylacetamides bearing electron donating groups at m-position. However, yields of quinolines having electron donating groups are good in all cases. Further, the nucleophilic substitution reaction of the quinolines is also investigated. Similarly, the formyl group in the quinolines is subjected to further transformation into cyano (CAN-NH3) and alkoxycarbonyl (NIS-K2CO3/alcohols) groups to afford corresponding 3-cyano and 3-alkoxycarbonylquinolines, respectively.