880106-49-0Relevant academic research and scientific papers
Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase
Ohkanda, Junko,Strickland, Corey L.,Blaskovich, Michelle A.,Carrico, Dora,Lockman, Jeffrey W.,Vogt, Andreas,Bucher, Cynthia J.,Sun, Jiazhi,Qian, Yimin,Knowles, David,Pusateri, Erin E.,Sebti, Said M.,Hamilton, Andrew D.
, p. 482 - 492 (2008/02/04)
A series of imidazole-containing peptidomimetic PFTase inhibitors and their co-crystal structures bound to PFTase and FPP are reported. The structures reveal that the peptidomimetics adopt a similar conformation to that of the extended CVIM tetrapeptide,
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
Ohkanda, Junko,Lockman, Jeffrey W.,Yokoyama, Kohei,Gelb, Michael H.,Croft, Simon L.,Kendrick, Howard,Harrell, Maria Isabel,Feagin, Jean E.,Blaskovich, Michelle A.,Sebti, Said M.,Hamilton, Andrew D.
, p. 761 - 764 (2007/10/03)
Malaria continues to represent a very serious health problem in the tropics. The current methods of clinical treatment are showing deficiencies due to the increased incidence of resistance in the parasite. In the present paper we report the design, synthe
