88012-22-0Relevant academic research and scientific papers
De novodesign and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions
Gao, Wenjing,Ma, Nana,Wan, Yameng,Wu, Hao,Zhang, Guisheng,Zhang, Zhiguo,Zhao, Jie
, p. 15988 - 15997 (2021/12/30)
Described here is thede novodesign and synthesis of a series of 6H-dipyrido[1,2-e:2′,1′-i]purin-6-ones (DPs) as a new class of visible-light photoredox catalysts (PCs). The synthesizedDP1-5showed theirλAbs(max)values in 433-477 nm, excited state redox potentials in 1.15-0.69 eV and ?1.41 to ?1.77 eV (vs.SCE), respectively. As a representative,DP4enables the productive guanylation of various amines, including 1°, 2°, and 3°-alkyl primary amines, secondary amines, aryl and heteroaryl amines, amino-nitrile, amino acids and peptides as well as propynylamines and α-amino esters giving diversities in biologically important guanidines and cyclic guanidines. The photocatalytic efficacy ofDP4in the guanylation overmatched commonly used Ir and Ru polypyridyl complexes, and some organic PCs. Other salient merits of this method include broad substrate scope and functional group tolerance, gram-scale synthesis, and versatile late-stage derivatizations that led to a derivative81exhibiting 60-fold better anticancer activity against Ramos cells with the IC50of 0.086 μM than that of clinical drug ibrutinib (5.1 μM).
Reactions of Heteroaryliminotriphenylphosphoranes with Heterocumulenes: Synthesis and Cycloaddition Reactions of α-N-Heteroaryl-substituted Carbodiimides
Boedeker, J.,Courault, K.,Koeckritz, A.,Koeckritz, P.
, p. 463 - 474 (2007/10/02)
N-α-Heteroaryl-substituted iminotriphenylphosphoranes react with phenylisocyanate, phenylisothiocyanate, and carbon disulfide to symmetrical and unsymmetrical α-heteroarylcarbodiimides.These can not be isolated as monomeres because they behave as 1.3-diazabutadienes predominantly and form 4+2-cycloadducts.The monomeric intermediates cyclodimerize to the 1.3.5-triazines 5 resp. 14 or react by the same scheme both with phenylisocyanate and with phenylisothiocyanate to give the 1.3.5-triazines 4, resp. 12.In competition with this reaction a 2+2-cycloaddition takes place, hence there follow numerous by-products.The structure of 1.3.5- triazines is determined from hydrolysis to guanidines 6 and on the basis of spectroscopic methods.
