880138-72-7

Upstream product

• 880138-66-9 L-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 162491-34-1 L-(R,R)-2-ethoxy-1,3-dioxolane-4,5-dicarboxylic acid diethyl ester 
• 880138-63-6 L-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolanoic acid] 

Downstream Products

• 939431-45-5 5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 
• 939431-46-6 C₅₄H₆₀N₅O₂₂P 

Relevant academic research and scientific papers

Chemical properties of 4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl (DECDO) as a hydroxyl protecting group of the 2′-hydroxyl function in ribonucleosides

(Chemical Equation Presented) We describe basic chemical properties of 4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl (DECDO) in view of its use as a protecting group for the 2′-hydroxyl function of ribonucleosides. The DECDO group is found to be compatible wit

4,5-Bis(ethoxycarbonyl)-[1,3]dioxolan-2-yl as a new orthoester-type protecting group for the 2′-hydroxyl function in the chemical synthesis of RNA

We wish to report 4,5-bis(ethoxycarbonyl)-[1,3]dioxolan-2-yl as a new protecting for the 2′-hydroxyl function. Our cyclic orthoester-type group is compatible with the DMTr strategy for oligonucleotide synthesis. This group was introduced to the 2′-hydroxy