88016-31-3

Usage

Uses

Used in Pharmaceutical Industry:
Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester is used as a reagent in the synthesis of pharmaceuticals for its ability to facilitate various chemical reactions. It aids in the production of new drug molecules and contributes to the development of innovative treatments.
Used in Agrochemical Industry:
In the agrochemical industry, Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester is utilized as a reagent in the synthesis of agrochemicals, such as pesticides and herbicides. Its application helps in the development of effective crop protection products.
Used in Chemical Production:
Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester serves as an intermediate in the production of other chemicals and materials. Its role in chemical synthesis allows for the creation of a wide range of products used in various industries.
Used in Organic Chemistry Research:
As a reagent in organic chemistry, Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester is used in research to explore new reactions and develop novel synthetic pathways. Its application in research contributes to the advancement of chemical knowledge and the discovery of new compounds.

Upstream product

• 96-35-5 glycolic acid methyl ester 
• 6832-16-2 methyl diazoacetate 
• 292638-85-8 acrylic acid methyl ester 
• 54761-04-5 ytterbium(III) triflate 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 5199-50-8 methyl 2-iodoacetate 

Downstream Products

• 1417526-07-8 methyl-2-(2-((4-fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetate 
• 171818-52-3 (3-Benzylsulfanyl-propylamino)-acetic acid methyl ester 
• 171818-51-2 (2-Benzylsulfanyl-ethylamino)-acetic acid methyl ester 

Relevant academic research and scientific papers

Access to Stable Quaternary Phosphiranium Salts by P-Alkylation and P-Arylation of Phosphiranes

We report the preparation of phosphiranium salts by quaternarization of phosphiranes, a class of sensitive, highly strained, and poorly nucleophilic cyclic phosphines. High-yielding introduction of a varied set of alkyl groups including methylene ester ar

HERBICIDAL COMPOUNDS

The present invention relates to herbicidally active thiadiazole derivatives, as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising such derivatives, as well as to the use of such compounds and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, in crops of useful plants.

Regioselectivity of thiouracil alkylation: Application to optimization of Darapladib synthesis

Darapladib is one of the most potent Lp-PLA2 (Lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 0.25 nM. We demonstrate that a crucial step of Darapladib synthesis was not correctly described in the litera

Dehydration-type Ti-Claisen Condensation (Carbonhomologation) of α-Heteroatom-substituted Acetates with Alkyl Formates: Utilization as (Z)-Stereodefined Cross-coupling Partners and Application to Concise Synthesis of Strobilurin A

TiCl4?Et3N or ?Bu3N reagent conducted a highly (Z)-stereoselective carbon homologation (dehydration type Ti-Claisen condensation) of alkyl α-heteroatom (halo and sulfonyloxy)-substituted acetates (XCH2CO2R) with alkyl formates (HCO2R) to afford various alkyl β-alkoxy-α-halo or sulfonyloxy-substituted acrylates (24 examples; 51%–91% yield). Stereoretentive Suzuki-Miyaura, Negishi, and Sonogashira cross-couplings using the obtained methyl β-methoxy-α-halo or sulfonyloxy-substituted acrylates proceeded smoothly to produce a variety of β-alkoxy-α-substituted acrylates in moderate to high yield (35 examples; 29%–99% yield). As a successful application, a 3-step straightforward synthesis of strobilurin A was performed utilizing the present reaction sequence (dehydration type Ti-Claisen condensation and Suzuki-Miyaura cross-coupling), wherein the geometry of the three consecutive olefins (2E,3Z,5E) was completely maintained. (Figure presented.).

Reactions of diazo esters with electron-deficient alkenes in the presence of Lewis acids

1,3-Dipolar cycloaddition reaction of diazo esters to electron-deficient dipolarophiles to yield the corresponding 1- or 2-pyrazolines was found to be significantly accelerated with Lewis acids (Yb(OTf)3, Sc(OTf) 3, GaCl3, EtAlCl2). The use of GaCl3 as the catalyst leads to the acceleration not only of the 1,3-dipolar cycloaddition reaction, but also subsequent insertion of the CHCO2Me electrophilic fragment of methyl diazoacetate into the N-H bond of 2-pyrazolines formed. Such Lewis acids as SnCl4, BF3, TiCl4, and In(OTf)3 are not efficient in the described processes, since they rapidly decompose starting diazo compounds.

Synthesis, characterization and solubility studies of four new highly water soluble 1,3,5-triaza-7-phosphaadamantane (PTA) salts and their gold(I) complexes

The synthesis of new water soluble N-alkylated derivatives of 1,3,5-triaza-7-phosphaadamantane is presented. The compounds were characterized by means of NMR and IR spectroscopy, mass spectrometry, high resolution mass spectrometry, elemental analysis and

ENDOTHELIN RECEPTOR ANTAGONISTS

The present invention relates to dihydroisoindole compounds, pharmaceutical compositions containing these compounds, and their use as endothelin receptor antagonists.