88016-31-3

Basic information

• Product Name: Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester
• Synonyms: Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester;Methyl 2-(((trifluoromethyl)sulfonyl)oxy)acetate
• CAS NO: 88016-31-3
• Molecular Formula: C₄H₅F₃O₅S
• Molecular Weight: 222.1397096
• Mol File: 88016-31-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 191.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.566±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester(88016-31-3)
• EPA Substance Registry System: Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester(88016-31-3)

Safety Data

• Hazardous Substances Data: 88016-31-3(Hazardous Substances Data)

Usage

General Description

Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester is a chemical compound with the molecular formula C4H5F3O5S. It is commonly known as methyl trifluoromethanesulfonate and is used as a reagent in organic chemistry for various reactions. It is a colorless liquid with a pungent odor and is highly flammable. Acetic acid, 2-[[(trifluoroMethyl)sulfonyl]oxy]-, Methyl ester is known for its use in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other chemicals and materials. The substance is considered hazardous and should be handled with care in a controlled laboratory setting.

Upstream product

• 6832-16-2 methyl diazoacetate 
• 292638-85-8 acrylic acid methyl ester 
• 54761-04-5 ytterbium(III) triflate 
• 96-35-5 glycolic acid methyl ester 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 5199-50-8 methyl 2-iodoacetate 

Downstream Products

• 171818-51-2 (2-Benzylsulfanyl-ethylamino)-acetic acid methyl ester 
• 1417526-07-8 methyl-2-(2-((4-fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)acetate 
• 171818-52-3 (3-Benzylsulfanyl-propylamino)-acetic acid methyl ester 

Relevant articles and documents

Access to Stable Quaternary Phosphiranium Salts by P-Alkylation and P-Arylation of Phosphiranes

We report the preparation of phosphiranium salts by quaternarization of phosphiranes, a class of sensitive, highly strained, and poorly nucleophilic cyclic phosphines. High-yielding introduction of a varied set of alkyl groups including methylene ester ar

Regioselectivity of thiouracil alkylation: Application to optimization of Darapladib synthesis

Darapladib is one of the most potent Lp-PLA2 (Lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 0.25 nM. We demonstrate that a crucial step of Darapladib synthesis was not correctly described in the litera

Reactions of diazo esters with electron-deficient alkenes in the presence of Lewis acids

1,3-Dipolar cycloaddition reaction of diazo esters to electron-deficient dipolarophiles to yield the corresponding 1- or 2-pyrazolines was found to be significantly accelerated with Lewis acids (Yb(OTf)3, Sc(OTf) 3, GaCl3, EtAlCl2). The use of GaCl3 as the catalyst leads to the acceleration not only of the 1,3-dipolar cycloaddition reaction, but also subsequent insertion of the CHCO2Me electrophilic fragment of methyl diazoacetate into the N-H bond of 2-pyrazolines formed. Such Lewis acids as SnCl4, BF3, TiCl4, and In(OTf)3 are not efficient in the described processes, since they rapidly decompose starting diazo compounds.