880177-58-2Relevant academic research and scientific papers
Synthetic approach to alkoxy-β-(trifluoromethyl)styrenes and their application in the synthesis of new trifluoromethylated heterocycles
Muzalevskiy, Vasiliy M.,Nenajdenko, Valentine G.,Shastin, Aleksey V.,Balenkova, Elizabeth S.,Haufe, Guenter
experimental part, p. 2249 - 2259 (2009/12/27)
A new convenient stereoselective pathway to alkoxy-β-(trifluoromethyl) styrenes is described. Reactions of β-chloro- and β-bromo-β- (trifluoromethyl)styrenes with sodium methoxide and potassium tert-butoxide led to methoxy- and tert-butoxy-β-(trifluoromethyl) styrenes in good to excellent yields. Bromination of tert-butoxy-β-(trifluoromethyl)styrenes proceeded with formation of aryl(bromo)methyl trifluoromethyl ketones. The latter compounds were found to be useful starting materials for the synthesis of different heterocyclic compounds bearing a trifluoromethyl group. In this way trifluoromethylated derivatives of imidazopyridine, imidazopyrimidine, imidazobenzimidazole, imidazothiazole, thiazole, and aminothiazole were obtained in moderate to high yield. Georg Thieme Verlag Stuttgart.
BENZIMIDAZOLYL-PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
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, (2008/06/13)
The invention relates to compounds of formula (XVI): (XVI) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein Y2, Z, L1, R9, R10, m and u are defined herein. These compounds ar
COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
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Page/Page column 129-130, (2010/10/20)
The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
