880384-46-3Relevant academic research and scientific papers
Short and simple preparation of N-Boc-protected anthranilic acid tert-butyl esters from 2-bromo-anilines
Herzig, Silvia,Kritter, Stéphane,Lübbers, Thomas,Marquardt, Nadine,Peters, Jens-Uwe,Weber, Silja
, p. 3107 - 3108 (2007/10/03)
A novel two-step procedure for the preparation of diprotected anthranilic acid derivatives from ortho-bromoanilines is described. Georg Thieme Verlag Stuttgart.
An improved synthesis of N-Boc protected aryl amines
Darnbrough,Mervic,Condon,Burns
, p. 3273 - 3280 (2007/10/03)
There are several known methods of protecting amines as their Boc derivatives. For less nucleophilic amines such as aryl amines these methods often give poor yields and are generally not satisfactory. Here, Boc aryl amines are obtained by first introducing two Boc groups followed by selective removal of one of them. This procedure works well for a number highly sterically hindered substrates as well as electron deficient and electron rich aryl amines.
