880384-50-9

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 583-68-6 2-bromo-p-toluidine 

Downstream Products

• 1380305-76-9 diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate 
• 1257996-86-3 diethyl (4-amino-3-bromobenzyl)phosphonate 
• 1257996-87-4 di-tert-butyl [2-bromo-4-(bromomethyl)phenyl]imidodicarbonate 
• 809231-04-7 (4-methyl-2-vinylphenyl)carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

MACROCYCLIC KINASE INHIBITORS

Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial.

AMINO PYRIMIDINE ANTICANCER COMPOUNDS

Compounds of Formula (1), as shown below and defined herein: and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.

Short and simple preparation of N-Boc-protected anthranilic acid tert-butyl esters from 2-bromo-anilines

A novel two-step procedure for the preparation of diprotected anthranilic acid derivatives from ortho-bromoanilines is described. Georg Thieme Verlag Stuttgart.

Indole synthesis by controlled carbolithiation of o-aminostyrenes

An effective synthesis of the functionalized indole ring system has been developed from substituted o-aminostyrene starting material. Our methodology involves a novel cascade reaction sequence of alkyllithium addition to the styrene double bond and subsequent trapping of the intermediate organolithium with a suitable electrophile, followed by an in situ ring closure and dehydration to generate the indole ring. This new reaction sequence allows for the introduction of molecular diversity at all positions on the indole scaffold. The procedure was shown to be successful with a range of both C and N substituents on the o-aminostyrenes. The reaction sequence was tolerant to the reactivity range of alkyllithiums such as tert-, sec-, and n-butyllithium. The electrophiles used were DMF, which generated indole products with C-2 unsubstituted, and nitriles, which incorporated the nitrile substituent at C-2. The o-aminostyrene starting materials were generated by a Pd-catalyzed cross-coupling reaction of a vinyl boronic acid equivalent with the readily available substituted o-bromoanilines.