880494-18-8

Basic information

• Product Name: 2-Thiazolamine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(2-nitrophenyl)-
• CAS NO: 880494-18-8
• Molecular Formula: C17H13N3O4S
• Molecular Weight: 355.374
• Mol File: 880494-18-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Thiazolamine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolamine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(2-nitrophenyl)-(880494-18-8)
• EPA Substance Registry System: 2-Thiazolamine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(2-nitrophenyl)-(880494-18-8)

Safety Data

• Hazardous Substances Data: 880494-18-8(Hazardous Substances Data)

Upstream product

• 420130-76-3 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)thiourea 
• 6851-99-6 2-bromo-1-(2-nitrophenyl)ethanone 

Downstream Products

• 880494-19-9 [4-(2-aminophenyl)thiazol-2-yl]-(2,3-dihydrobenzo[1,4]dioxin-6-yl)amine 

Relevant articles and documents

Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines

Oxadiazole derivatives were synthesized and evaluated for their ability to inhibit tubulin polymerization and to cause mitotic arrest in tumor cells. The most potent compounds inhibited tubulin polymerization at concentrations below 1 μM. Lead analogs caused mitotic arrest of A431 human epidermoid cells and cells derived from multi-drug resistant tumors (10, EC50 = 7.8 nM). Competition for the colchicine binding site and pharmacokinetic properties of selected potent compounds were also investigated and are reported herein, along with structure-activity relationships for this novel series of antimitotic agents.