880495-01-2Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationship of novel thiophene derivatives for β-amyloid plaque imaging
Chandra, Rajesh,Kung, Mei-Ping,Kung, Hank F.
, p. 1350 - 1352 (2007/10/03)
Novel 2,5-diphenylthiophene derivatives were synthesized and structure activity relationship with regard to Aβ plaque binding was studied. Binding affinities of these compounds were found to range from 3.9 to >1000 nM, depending on the substitution patter
