88054-95-9Relevant academic research and scientific papers
3-Alkyl-2-phenyl-1-vinylpyrroles from ketoximes and acetylene: An improved synthesis by the Trofimov reaction
Petrova,Sobenina,Mikhaleva
, p. 1628 - 1633 (2013/06/27)
A one-pot synthesis of 3-alkyl-2-phenyl-1-vinylpyrroles, giving high yields at atmospheric pressure, was developed on the basis of reacting alkyl phenyl ketoximes with acetylene in a KOH-DMSO system (the Trofimov reaction).
PYRROLES FROM KETOXIMES AND ACETYLENE. 30. THE SYNTHESIS OF 3-ALKYL-2-ARYLPYRROLES
Korostova, S. E.,Mikhaleva, A. I.,Sobenina, L. N.,Shevchenko, S. G.,Shcherbakov, V. V.
, p. 1238 - 1241 (2007/10/02)
Conditions were found for the synthesis of 3-alkyl-2-arylpyrroles using the Trofimov reaction at 50-70 deg C both at elevated and atmospheric pressure.O-Vinyloximes and 3H-5-hydroxy-4,5-dihydropyrroles were isolated as intermediates.
PYRROLES FROM KETOXIMES AND ACETYLENE. XXVI. THE SYNTHESIS OF NEW 2-ARYLPYRROLES
Korostova, S. E.,Sobenina, L. N.,Nesterenko, R. N.,Aliev, I. A.,Mikhaleva, A. I.
, p. 1790 - 1793 (2007/10/02)
New representatives of the 2-arylpyrrole series were obtained with yields of 36-90percent from the oximes of alkyl aryl ketones by the Trofimov reaction.When vinyl chloride was used instead of acetylene under the same conditions (potassium hydroxide-DMSO, 80-100 deg C), the pyrroles were obtained with yields of 2-7percent.
