88059-54-5Relevant academic research and scientific papers
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening
Pibiri, Ivana,Lentini, Laura,Tutone, Marco,Melfi, Raffaella,Pace, Andrea,Di Leonardo, Aldo
, p. 429 - 435 (2016/07/15)
Ataluren, also known as PTC124, is a 5-(fluorophenyl)-1,2,4-oxadiazolyl-benzoic acid suggested to suppress nonsense mutations by readthrough of premature stop codons in the mRNA. Potential interaction of PTC124 with mRNA has been recently studied by molec
The accelerated development of an optimized synthesis of 1,2,4-oxadiazoles: Application of microwave irradiation and statistical design of experiments
Evans, Marc D.,Ring, Jessica,Schoen, Adam,Bell, Andrew,Edwards, Paul,Berthelot, Didier,Nicewonger, Robb,Baldino, Carmen M.
, p. 9337 - 9341 (2007/10/03)
Herein, we report the development of an optimized microwave-assisted synthesis of 1,2,4-oxadiazoles. The chemistry development process was significantly accelerated by employing a statistical software package (MODDE 6.0) to guide in the optimization of the reaction conditions. The resulting optimized reaction conditions were then utilized in the synthesis of a focused library of 1,2,4-oxadiazoles.
Synthesis of 5-aryl-3-(4-pyridyl)-1,2,4-oxadiazoles
Brana,Castellano,Yunta
, p. 1403 - 1405 (2007/10/02)
The title oxadiazoles were formed in the reaction of N-(4-pyridylmethyl)arylamides with nitrosyl chloride in low yields.
