88062-88-8

Basic information

• Product Name: Benzenesulfonamide, 4-(4,5,6,7-tetrachloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
• CAS NO: 88062-88-8
• Molecular Formula: C14H6Cl4N2O4S
• Molecular Weight: 440.091
• Mol File: 88062-88-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-(4,5,6,7-tetrachloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-(4,5,6,7-tetrachloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-(88062-88-8)
• EPA Substance Registry System: Benzenesulfonamide, 4-(4,5,6,7-tetrachloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-(88062-88-8)

Safety Data

• Hazardous Substances Data: 88062-88-8(Hazardous Substances Data)

Upstream product

• 117-08-8 tetrachlorophthalic anhydride 
• 63-74-1 sulfanilamide 

Relevant articles and documents

Synthesis and human carbonic anhydrase I, II, IX, and XII inhibition studies of sulphonamides incorporating mono-, Bi- and tricyclic imide moieties

New derivatives were synthesised by reaction of amino-containing aromatic sulphonamides with mono-, bi-, and tricyclic anhydrides. These sulphonamides were investigated as human carbonic anhydrases (hCAs, EC 4.2.1.1) I, II, IX, and XII inhibitors. hCA I w

Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2

A group of cyclic imides (1-10) was designed for evaluation as a selective COX-2 inhibitors and investigated in vivo for their anti-inflammatory activity. Compounds 6a, 6b, 8a, 8b, 9a, 9b, 10a and 10b were proved to be potent COX-2 inhibitors with IC50 range of 0.1-4.0 μM. In vitro COX-1/COX-2 inhibition structure-activity studies identified compound 8a as a highly potent (IC50 = 0.1 μM), and an extremely selective [COX-2 (SI) > 1000] comparable to celecoxib [COX-2 (SI) > 384], COX-2 inhibitor that showed superior anti-inflammatory activity (ED50 = 72.4 mg/kg) relative to diclofenac (ED50 = 114 mg/kg). Molecular modeling was carried out through docking the designed compounds into the COX-2 binding site to predict if these compounds have analogous binding mode to the COX-2 inhibitors. The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2 -pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln192(2.95 A?), Phe 518(2.82 A?) and Arg513(2.63 and 2.73 A?). Docking study of the synthesized compound 8a into the active site of COX-2 revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.