880643-66-3

Upstream product

• 74124-79-1 di(succinimido) carbonate 
• 845272-39-1 1-[2-(4-bromophenyl)ethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 
• 845273-49-6 1-{2-[4-(9-hydroxy-3-methoxythioxanthen-9-yl)phenyl]ethyl}-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 
• 26419-32-9 3-methoxy-9H-thioxanthen-9-one 

Downstream Products

• 880567-29-3 3-{4-[9-(3-hydroxy-butoxy)-3-methoxy-10-oxo-9,10-dihydro-10λ⁴-thioxanthen-9-yl]-phenyl}-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester 

Relevant academic research and scientific papers

Reactive trityl derivatives: Stabilised carbocation mass-tags for life sciences applications

The rational design of novel triarylmethyl (trityl)-based mass tags (MT) for mass-spectrometric (MS) applications is described. We propose a "pKR+ rule" to correlate the stability of trityl carbocations with their MS performance: trityls with higher pKR+ values ionise and desorb better. Trityl blocks were synthesised that have high pKR+ values and are stable in conditions of MS analysis; these MTs can be ionised by matrix as well as irradiation with a 337 nm nitrogen laser. 13C-Labelled tags were prepared for MS quantitation applications. Moreover, the tags were equipped with a variety of functional groups allowing conjugation with different functionalities within (bio)molecules to enhance the MS characteristics of the latter. The MS behaviour of model polycationic trityl compounds with and without the matrix was studied to reveal that poly-trityl clusters are always singly charged under the (MA)LDI-TOF conditions. Several peptide-trityl conjugates were prepared and comparisons revealed a beneficial effect of trityl tags on the conjugate detection in MS. Trityl compounds containing para-methoxy- and dimethylamine groups, as well as a xanthene fragment, showed considerable enhancement in MS detection of model peptides; thus they are promising tools for proteomic applications. Dimethoxytrityl derivatives allow one to distinguish between Arg- and Lys-containing peptides. Maleimido trityl derivatives are suitable for the efficient derivatisation of thiol-containing peptides in pyridine.

S(O)-pixyl protecting group as efficient mass-tag

We report herein the design, preparation and first applications of novel trityl tags with adjustable stability, efficient as protecting groups or MS analytes. The Royal Society of Chemistry 2005.

Derivatised molecules for mass spectrometry

Compounds of formula (IIa): are provided where:X is a group capable of being cleaved from the α-carbon atom to form an ion of formula (I')C is a carbon atom bearing a single positive charge or a single negative charge; The invention further provides compounds of formula (IIb): where:X is a counter-ion to C. The compounds of formula (IIa) and (IIb) may form ions of formula (I') by either cleaving the C-X bond between X and the α-carbon atoms in the case of the compounds of formula (IIa) or dissociating X in the case of compounds of formula (IIb).