880648-99-7Relevant academic research and scientific papers
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17- O, O -bis-sulfamate
Jourdan, Fabrice,Leese, Mathew P.,Dohle, Wolfgang,Hamel, Ernest,Ferrandis, Eric,Newman, Simon P.,Purohit, Atul,Reed, Michael J.,Potter, Barry V. L.
supporting information; experimental part, p. 2942 - 2951 (2010/08/05)
The synthesis and antiproliferative activity of analogues of estradiol 3,17-O,O-bis-sulfamates (E2bisMATEs) are discussed. Modifications of the C-17 substituent reveal that an H-bond acceptor is essential for high antiproliferative activity. The local env
