880650-03-3

Basic information

• Product Name: Benzene, 1,3-dimethoxy-5-(2,2,2-trifluoro-1-methylethyl)-
• CAS NO: 880650-03-3
• Molecular Formula: C11H13F3O2
• Molecular Weight: 234.218
• Mol File: 880650-03-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzene, 1,3-dimethoxy-5-(2,2,2-trifluoro-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dimethoxy-5-(2,2,2-trifluoro-1-methylethyl)-(880650-03-3)
• EPA Substance Registry System: Benzene, 1,3-dimethoxy-5-(2,2,2-trifluoro-1-methylethyl)-(880650-03-3)

Safety Data

• Hazardous Substances Data: 880650-03-3(Hazardous Substances Data)

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 14950-55-1 rac-1-(3,5-dimethoxyphenyl)ethan-1-ol 
• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 
• 1620096-71-0 1-(1,1-difluoroprop-1-en-2-yl)-3,5-dimethoxybenzene 

Relevant articles and documents

Metal-free trifluoromethylation of aromatic and heteroaromatic aldehydes and ketones

The ability to convert simple and common substrates into fluoroalkyl derivatives under mild conditions remains an important goal for medicinal and agricultural chemists. One representative example of a desirable transformation involves the conversion of aromatic and heteroaromatic ketones and aldehydes into aryl and heteroaryl β,β,β-trifluoroethylarenes and -heteroarenes. The traditional approach for this net transformation involves stoichiometric metals and/or multistep reaction sequences that consume excessive time, material, and labor resources while providing low yields of products. To complement these traditional strategies, we report a one-pot metal-free decarboxylative procedure for accessing β,β,β- trifluoroethylarenes and -heteroarenes from readily available ketones and aldehydes. This method features several benefits, including ease of operation, readily available reagents, mild reaction conditions, high functional-group compatibility, and scalability.