88069-67-4 Usage
General Description
Pilsicainide is a class I antiarrhythmic drug that is used to treat cardiac arrhythmias, specifically paroxysmal atrial fibrillation. It works by inhibiting sodium channels in the heart, leading to a decrease in the conduction and excitability of cardiac tissue. This helps to prevent the rapid and irregular heartbeats associated with atrial fibrillation and restore normal heart rhythm. Pilsicainide is administered orally and has a relatively fast onset of action, making it useful for acute treatment of atrial fibrillation episodes. Like many antiarrhythmic drugs, pilsicainide can cause proarrhythmic effects and may require close monitoring of cardiac function during treatment. Overall, pilsicainide is an important option for managing atrial fibrillation and related arrhythmias.
Check Digit Verification of cas no
The CAS Registry Mumber 88069-67-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,0,6 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 88069-67:
(7*8)+(6*8)+(5*0)+(4*6)+(3*9)+(2*6)+(1*7)=174
174 % 10 = 4
So 88069-67-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H24N2O/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20)
88069-67-4Relevant articles and documents
New Anthiarrythmic Agents. N-Aryl-8-pyrrolizidinealkanamides
Miyano, Seiji,Sumoto, Kunihiro,Satoh, Fumio,Shima, Keiyu,Hayashimatsu, Mariko,et al.
, p. 714 - 717 (2007/10/02)
The synthesis and antiarrhytmic activity of N-aryl-8-pyrrolizidinealkanamides are described.The targed compounds were evaluated for their ability to protect against chloroform-induced fibrillation in mice.Many of them were found to have antifibrillatory activity comparable to that of lidocaine; several are more potent than lidocaine.N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide (6n), which was found to be more potent and less toxic (LD50) than lidocaine, also showed a long duration of action in dogs with venticular arrhythmias after oral administration.