88072-56-4

Upstream product

• 96-32-2 bromoacetic acid methyl ester 
• 83044-30-8 Lithium; 4-tert-butyl-3-phenyl-4H-oxet-2-olate 
• 74686-98-9 ((2S,3R)-2-tert-Butyl-4-oxo-3-phenyl-oxetan-3-yl)-acetic acid methyl ester 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 

Relevant academic research and scientific papers

Diastereoselective Michael Additions of β-Lactone Enolates to Dimethyl Maleate

The Michael addition of the β-lactone enolates (4) to dimethyl maleate (5) proceeds with efficient stereocontrol of both of the newly formed chiral centres.

STEREOSELECTIVE ADDITIONS TO CARBOXYLIC ACID DIANIONS AND β-LACTONE SUBSTITUTED ESTER ENOLATES. APPLICATION TO THE SYNTHESIS OF RACEMIC EPI-BLASTMYCINONE, δ-MULTISTRIATINE, PARACONIC ESTERS AND LIGNANTYPE DILACTONES

New stereoselective syntheses are reported for racemic 4-epi-blastmycinone (6) and δ-multistriatine (13) utilizing the anti-configurated γ,δ-unsaturated β-hydroxy-carboxylic acids 2a/b.A diastereo- and enantioselective aldoltype addition of phenylacetic acid dianion to benzaldehyde has been achaived by employing optically active alkoxide amide bases.Finally, highly stereocontrolled additions to the novel β-lactone substituted ester enolates 22 are described.